Sabtu, 04 Februari 2012

Epigenetics again

At the moment everything seems to be about  epigenetics, mitochnodria or the microbiome.

Here is one about epigenetics - turning genes on or off:

Scientists at the University of California, San Francisco (UCSF) have identified nearly 200 genes in the healthy prostate tissue of men with low-grade prostate cancer that may help explain how physical activity improves survival from the disease.

Vigorous exercise linked to gene activity in prostate

Kamis, 02 Februari 2012

Massage post exercise reduces inflammation, builds mitochondria

I've mentioned before that I get a regular session of bodywork from my pal Colin at Edinburgh Deep Tissue Massage.  I enjoy the chat, he sorts out any strains or spasms that are going on and he also gives me some good coaching in general on posture, movement and exercise.

It seems that there are real clinic benefits to all this too.  I spotted this report of a new study on massage which explains :

While massage is well accepted as a therapy for relieving muscle tension and pain, the researchers delved deeper to find it also triggers biochemical sensors that can send inflammation-reducing signals to muscle cells.

In addition, massage signals muscle to build more mitochondria, the power centres of cells which play an important role in healing.

"The main thing, and what is novel about our study, is that no one has ever looked inside the muscle to see what is happening with massage, no one looked at the biochemical effects or what might be going on in the muscle itself," said Crane.

"We have shown the muscle senses that it is being stretched and this appears to reduce the cells' inflammatory response," he said. "As a consequence, massage may be beneficial for recovery from injury."

Really interesting stuff - cellular effects from massage which extend to generating more mitochondria.

As ever of course, Alex at Sweat Science got here first and has a much more detailed analysis of the research.

Cosmetics and Chemicals

This was interesting

Fatal Attraction
Created by: Cosmetology School

Curing ITB pain

a nice technique....from Martha Peterson

What I believe and what I don't.

First, some soothing music...


I've been getting into arguments on the Internet again! People assume that I believe certain things and "put words in my mouth". As we all know, assume makes an ass out of u and me. I am therefore "laying my cards on the table", so that you have no excuse for being ignorant.

I believe that human beings are extremely complicated creatures both physiologically and psychologically. Our weights are influenced by a humongous number of factors, some of which I will list below.


Physiology

Calories count (but don't bother counting them)! If we eat more than we use, we store the excess in fat mass and muscle mass. If we eat less than we use, we draw the deficit from fat mass and muscle mass. Insulin is involved in the storage of stuff, as is acylation stimulating protein (ASP).

Moving too little makes our skeletal muscle insulin resistant, as inactive muscles have virtually zero requirement for glucose and fatty acids, so down-regulate the uptake of them. See also The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women.

Eating too much and moving too little has sweet-F/A to do with gluttony and sloth.

Our weights are regulated by our brains, which are influenced by a large number of hormones & chemicals, including insulin. There is no "set point" weight.

In the winter, when it's cold and dark, we eat more, sleep more and move less so we gain body fat. Subcutaneous fat acts as heat insulation, so having more of it in the winter makes sense.

Our weights can be affected by water balance, which is controlled by our kidneys.

How much of a particular food we eat is influenced by reward. Some foods can be addictive (or moreish, as we say in the UK) due to excessive reward. Deliciousness and moreishness are not the same thing. Reward theory and set-point theory are not the same thing.

Rapidly-falling blood glucose level in the normal range can stimulate appetite. I have had personal experience of this on three occasions where my blood glucose level was being monitored. As eating a load of high-glycaemic carbohydrates can result in rapidly-falling blood glucose later, this is another good reason to not overeat refined carbohydrates.


Psychology

The exercise paradox. Exercise decreases appetite*. So, why do some people eat more when they exercise more? See Normal Weight Men and Women Overestimate Energy Expenditure – Research Review and Discrepancy between self-reported and actual caloric intake and exercise in obese subjects.

*If exercise increases your appetite, there may be a reason for this. See Move More: Solutions to problems.

The diet paradox. People think that eating a healthy food with an unhealthy food reduces the calories, discussed in detail in The Dieter’s Paradox – Research Review.

Manipulating the masses is easier than you think.

The Coolidge Effect applies to food as well as sex. Eating one food for every meal gradually reduces reward to zero, no matter how moreish it may be initially. This is how the Potato diet worked.


I often leave very concise comments on blogs. Just because I don't mention this, that or the other doesn't mean that I consider this, that or the other to be irrelevant. I can also go on a bit. I'm a nerd!

EDIT: If I disagree with your point of view, I may try to tease more information out of you (or I may tease you just for fun). The more I disagree with your point of view, the more I'll tease you. If I utterly abhor something you stand for, I will tease you mercilessly!